XRCC1 R399Q (G/A)

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Research Focus

Research suggests that platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of DNA repair genes are associated with differential DNA repair activity and are under investigations to increase the understanding of interindividual differences in overall survival after therapy with platinum agents for cancer.

Target Disease/Application

DNA repair genes polymorphisms

Assay ID dbSNP ID Location Gene Symbol Gene Name SNP Type  
C____622564_10 rs25487 Chr.19: 44055726 XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 Mis-sense Mutation
Transition Substitution

Specifications

General Specifications

# of assays: 1
Technology: TaqMan® Assays - Pre-formulated assay (20x or 60x mix)
Scale: Available in multiple scales
Intended Use: Research Use Only

Kit Storage

-20° C

 

Citations & References (2)

  • XPD and XRCC1 Genetic Polymorphisms Are Prognostic Factors in Advanced Non—Small-Cell Lung Cancer Patients Treated With Platinum Chemotherapy

Authors
Sarada Gurubhagavatula et al.
Journal
Journal of Clinical Oncology, Vol 22, No 13 (July 1), 2004: pp. 2594-2601

  • Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients

Authors
de las Penas et al.
Journal
Annals of Oncology 17: 668–675, 2006 R.
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