Research Focus

Acute myelogenous leukemia (AML) with t(8;21)(q22;q22) is an acute myelogenous leukemia generally showing maturation in the neutrophil lineage. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. Acute myelogenous leukemia (AML) with t(8;21)(q22;q22) is one of the most common structural aberrations in AML and can be found in 5-12% of cases of AML and in one third of karyotypically abnormal cases of AML with maturation. It occurs predominantly in younger patients.

Target Disease/Application

Acute myeloid leukemia (AML)

Chromosomal Alteration

t(8;21)(q22;q22)